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Her 2 pozitiv forum

her2 pozitiv Secțiunea: Interpretare analize si examen anatomopatologic. 1 comentarii 1. 1 valibrat: 1 valibrat [3c] 28-09-2009, 14:00. Membru din 03-09-2009. Subiecte: 3. Comentarii: 3. .Ma bucur mult ca am gasit acest forum unde pot sa gasec intelegere.. D-le doctor, in urma operatiei au fost scosi si studiati 20 de ganglioni, prietena mea are 47 de ani si ea a optat pentru acest gen de operatie, fiind influentata de rezultatul primei biopsii: HER 2 pozitiv si GR. III.Face si tratament cu tamoxifen

her2 pozitiv Forum despre Cance

Cancerul mamar HER2-pozitiv. 30% dintre pacientele diagnosticate cu tumoră malignă de sân au markerul HER-2 pozitiv, fapt ce determină creșterea agresivității cancerului, a riscului de recurenţă şi scăderea sensibilităţii la terapia hormonală Áttétes emlőrákban kettős HER-2 gátlás kemoterápiával kombinálva. A kezelés formái. Intravénás: a legtöbb HER-2 ellenes célzott terápiát intravénás infúzió formájában adják egy vénába helyezett kanülön keresztül. Ilyen például a trastuzumab, a pertuzumab és a trastuzumab-emtansin is -Imunohistochimic-Caderina E-pozitiv intens in celule tumorale, ER pozitiv 80%, PGR pozitiv 30%, CerbB2 negativ, Ki67 pozitiv 25%. Concluzii-Metastaza ganglionara de carcinom mamar de tip mucinos, pozitiv pentru receptori hormonali, HER 2 NEGATIV. Multumesc anticipat

Daca un cancer de san este HER-2/neu pozitiv si testul HER-2/neu seric da valori initial ridicate, modificarile concentratiilor serice HER-2/neu pot fi folosite la monitorizarea eficacitatii tratamentului cu Herceptin si la detectia precoce a bolii. Scaderea valorilor indica un raspuns bun la tratament Mit jelent ez? Jó hír? Rossz hír? abból a szempontból rossz hír, hogy a her2 pozitivitás a prognózisnak nem kedvez, viszont van célzott kezelése, a herceptin. ha van még kérdésed, szólj! Az enyém hormonérzékeny, de szerencsére HER2 negatív. Így is a mérsékelt prognózisú II-be tartozom Un nou tratament eficient pentru cancerul de stomac. Un medicament folosit astazi cu succes in tratarea pacientelor bolnave de cancer la san HER-2 pozitiv este eficient si in tratamentul persoanelor afectate de cancer de stomac. Rezultatele studiului clinic ToGA prezentat in cadrul celui mai important congres de oncologie, ASCO 2009, desfasurat. HER-2 / neu : +++ na svim tm stanicama Aksila: 0/2 Isječak nalaza druge biopsije poslije oper. zahvata 1. Tkivo dojke 12:8 cm s kožom na površini - Tumorsko tkivo nije nađeno 2. Materijal označen kao aksila je masno tkivo promjera 3 cm u kojem se nađu 2 limfna čvora promjera 0,5 i 0,9 cm . At the 2018 Metastatic Breast Cancer Forum, Heather A. Parsons, MD, MPH, and Ian E. Krop, MD, PhD, discuss research advances in the treatment of HER2-positiv..

Paclitaxel Ebewe 6 mg/ml concentrat pentru soluţie perfuzabilă (paclitaxelum) » Secțiunea: Medicamente...mare de HER-2 la un nivel 3+, determinat prin imunohistochimie, şi care nu au răspuns la terapia cu o antraciclină.Paclitaxelul este indicat ca monoterapie în tratamentul carcinomului denu a răspuns la tratamentul cu antracicline sub formă lipozomală HER2 is a growth-promoting protein on the outside of all breast cells. Breast cancer cells with higher than normal levels of HER2 are called HER2-positive. These cancers tend to grow and spread faster than other breast cancers, but are much more likely to respond to treatment with drugs that target the HER2 protein Femeile care au consumat mai multa soia, comparativ cu cele care au consumat o cantitate mica, prezentau un risc mai scazut de a face cancer, in urmatoarele procente: cele cu ER-pozitiv prezentau un risc mai scazut cu 26%, iar cele cu HER-2 negativ, un procent de 22% Her-2 Breast Cancer Outcomes Are Mitigated by Consuming n-3 Polyunsaturated, Saturated, and Monounsaturated Fatty Acids Compared to n-6 Polyunsaturated Fatty Acids. Nutrients. MDPI AG; 2020; 12:3901 10.3390/nu1212390 HER2 is a protein that causes breast cancer cells to grow, and it can cause aggressive breast cancer. Read about survival rates, treatments, and more

her 2 + Forumul Medical ROmedi

CK5, EGFR, p53 pozitiv HER2 10-15% HER2 pozitiv ER negativ Luminal A 40% ER, PR pozitiv intens HER2 negativ Luminal B 20% ER pozitiv/slab, HER2-/+ Ki67 crescut Normal like/neclasificabil 6-8% ER, PR, HER2, CK5, EGFR - Gene ţesut adipos Claudin low 12-14% ER-, Claudin 3/4/7 -/slab E-cadherin slab, Vim + După Malhorta et al, 2012, modifica HER2-positive breast cancer is a breast cancer that tests positive for a protein called human epidermal growth factor receptor 2 (HER2). This protein promotes the growth of cancer cells. In about 1 of every 5 breast cancers, the cancer cells have extra copies of the gene that makes the HER2 protein. HER2 -positive breast cancers tend to be more. Rezultatul Anatomo-Patologic. Am primit un rezultat anatomo (histo)-patologic. El poate contine diagnosticul histopatologic al unei piese operatorii sau al unei biopsii. Cel mai adesea oamenii intreaba ce sa faca cu el. Primul sfat: mergi la medicul care ti-a recoltat piesa si a trimis-o la Anatomie Patologica. Sigur stie el de ce

#ASCO19. Rezultate pozitive ale imunoterapiei și terapiei ..

Ki67 ist ein Protein, also ein Eiweiß, dass in bestimmten Phasen auf der Oberfläche einer Zelle sitzt und im Labor bestimmt werden kann. Da es nur in Wachstumsphasen auf der Zelloberfläche auftaucht, ist es ein guter Marker, um wachstumsaktive Zellen von gerade nicht wachstumsaktiven Zellen zu unterscheiden Chemoterapia po mastektómii prsníka. paj333. 6. dec 2016. Ahojte, mám 24 rokov, a pred necelými dvoma mesiacmi mi diagnostikovali karcinóm ľavého prsníka. Doktor na chirurgii odporúčal vybrať celú prsnú žľazu, lebo je to istejšie. Keby som chcela prsník ponechať, najskôr by som musela podstúpiť chemo, aby sa nádor zmenšil. Forum. Comunitate - Community. Discutii Generale - General Stuff 'Cause her only son is dyin' She don't know it's just your karma catchin' up Am primit raspunsul pozitiv in acest context. ar fi prea aiurea ca si cei de pe Phoenix sa astepte 3 zile la rand sau cat tine fuziunea fara a primi macar atat Sectorectomie mamara stanga » Secțiunea: Forum medical. Am fost operata in 09.11.2011, sectorectomie mamara stanga, s-au extirpat 2 noduli, rezultatul a fost -.MACRO - 2 piese de 6, 5 /7 /2prelucrata in proportie de 90 % - MICRO - Mastopatie fibrochistica in ambele piese. in piesa mare predomina adenoza ( simpla, si mai rar, florida, alternand cu focare de atrofilie lobulara ) si. Összegyűjtöttünk minden lényeges információt, amit az oldalunkon megtalál HER2 témakörben

Ha a daganat HER2-pozitív - Mellrákfóru

  1. Desi stiam in ce consta operatia - mastectomie radicala modificata dreapta adica in afara de san au scos si muschiul pectoral si o bucata de tesut adipos de la axila dreapta de 12 x 9 x 2 cm care includea 16 ganglioni limfatici - si stiam ca este absolut necesara, cand m-am trezit si m-am vazut mutilata a fost socant; multa vreme nu am putut.
  2. HER-2-neu positiv ist, zeigt Antikörper auf Herceptin; Nach einer OP und Bestrahlung kann eine antihormonelle Therapie mit z.b. Tamoxifen oder einem sog. Aromatase-Hemmer erfolgen. Ein triple-positiver Krebs weist auf eine sehr gute Heilungschance (abhängig von Stadium und genauer Histologie) Immune Reactive Score IRS (immunhistochemischer Score
  3. Cybermed je prvi hrvatski zdravstveni portal. Služi za zdravstveno educiranje stanovništva i stručno usavršavanje zdravstvenih djelatnika. Sadrži informacije i vijesti o zdravlju i očuvanju zdravlja, bolestima, čimbenicima rizika bolesti, lijekovima, pravilnoj primjeni lijekova te ranom otkrivanju i prevenciji bolesti

forum.index.hu. Magyarország első és legnagyobb fórum szolgáltatása. A web kettő pre-bétája, amit 1997 óta töltenek meg tartalommal a fórumlakók. Fórumok változatos témákban, hangnemben, moderálva. Ha nem csak megosztani akarsz, hanem diskurálni egy egy témában, csatlakozz Te is, és ha kitartó vagy, társakra találhatsz Få Danmarks bedste coronaoverblik med alle graferne over nyeste coronatal fra Danmark og verden. Så mange er smittede, indlagte og døde. Kilde: S tatens Serum Institut. Bemærk, at tallene her.

2. I have problems with my liver. I was a very healthy kid, and did a lot of sports semi-professionaly. In my school at 18 Years old, I was in a football, rowing and tennis team. I barely drink and eat properly and had a very healthy body composition. After he said I have problems with my liver, we went to a doctor and guess what - I had an. The IHC test uses a chemical dye to stain the HER2 proteins. The IHC gives a score of 0 to 3+ that measures the amount of HER2 proteins on the surface of cells in a breast cancer tissue sample. If the score is 0 to 1+, it's considered HER2-negative. If the score is 2+, it's considered borderline. A score of 3+ is considered HER2-positive

interpretare rezultat imunohistochimie Forum despre Cance

  1. gly peaceful centre of Valheim, but the gods reward the brave.
  2. Identificarea stadiilor de evoluție a infecției cu virusul hepatitic B. Traducere și adaptare după HEPATOLOGY, a clinical textbook, Mauss, Berg, Rockstroh, Sarrazin, Wedemeyer, 8 th Edition, 2017. Pentru reducerea morbidității și mortalitătii prin hepatită cronică cu VHB sunt necesare eforturi continue pentru identificarea persoanelor infectate printr-un screening țintit, prevenirea.
  3. g back reactive at 1:1 . She then did the confirmatory test for syphilis , TPPA.
  4. Her-2/neu wird zusammen mit dem Hormon Rezeptor Status bestimmt. Bei Patientinnen mit ER- und/oder PR-positiven Tumoren kann bei Positivität von Her-2/neu das Ansprechen der endokrinen Therapie verringert sein
  5. The problem with the ANA is that it can be found in normal healthy people. ANA 1:40 is found in 20 - 30% of healthy people. ANA 1:80 is found in 10 - 15% of healthy people. ANA 1:160 is found in 5% of healthy people. ANA 1:320 is found in 3% of healthy people. 5 - 25% of healthy people with a family member suffering from lupus have a.
  6. Feedback pozitiv. 17520. Retea parteneri. 429. Clienti. Logictrans Contact. Formular de comanda. Nume/Companie* E-mail* Telefon* Localitate incarcare* Data incarcare* Localitate descarcare* Cantitate/Volum* Tip transport* Comentarii* Cunoscându-ne foarte bine pe noi și mai puțin pe alții, vă încurajăm să ne contactați de fiecare dată.

Oncoproteina (Her 2/Neu) Reginamaria

NGO: GERMIN (www.germin.org) Position: Field Researcher Project: Co-Investment and Networking Forum - Invest in Vushtrri Application Deadline: 28 August 2020 Preferable starting Date: 05 September 2020 Location: Municipality of Vushtrri Background: GERMIN is a non-governmental organization whose core principles and ideals are based on the belief that the Albanian Diaspora must play an. A vastagbélrákok előrehaladott fajtáinak kezelésére jelenleg kétféle célzott kezelési módszer is az orvosok rendelkezésére áll. Az első esetben a daganatos erek képződését, a második esetben pedig az EGFR nevű fehérje működését gátolják a gyógyszerek. Az első esetben nem áll rendelkezésre molekuláris diagnosztikai vizsgálat, a második esetben viszont igen. Magyarország kezdőlapja: gyors hírek, feltárt tények, karcos vélemények. Fontos hírek: olimpia, pegasus-botrány, népszavazás, nagyon balato

Example 1: friend of mine is travelling to a danger state (high number of positive tests). Upon her return, she will voluntarily self-quarantine for 14 days while waiting for test results, because she is a good person and cares. Compliant. And seeking approval for her plan, which she knows she will get K: A szérum káliumion koncentráció mérése fontos információt szolgáltathat a folyadékháztartásról, hormonális hatásokról, számos betegségben alkalmazott terápia hatásosságáról. A lelet helyes értékeléséhez az orvosnak számos szempontot mérlegelnie kell Red Bull's Jonathan Wheatley tests positive for COVID-19. Bahrain Grand Prix - Red Bull's Sporting Director, Jonathan Wheatley, will miss this weekend's race in Bahrain after he tested positive for coronavirus. Wheatley, who has been part of the Red Bull Racing team since 2006, received the positive result after the pre-race round of. A székletben megjelenő vér a bélrendszerből származik. Mire a felsőbb szakaszokból származó vér a székletbe kerül, megemésztődik, és a székletet - ha nagy mennyiségű - feketére festi, a végbélből származó vér pedig friss piros színű. Kis mennyiségű vér nem okozza a széklet elszíneződését Spontán terhesség után A múlt év decemberi sikertelen spontán terhesség után, 2 hónap szünet következett, majd mentünk a Kaáliba, márciusban fogamzásgátló szedés és áprilisban indult a lombik, ami a 3. lombik kezelésem volt. Nem mondom hogy könnyű volt 15 hónapos kislánnyal járkálni 2-3 naponta 100 km-eket oda-vissza.

HER2 pozitív - Mellrákfóru

Ellen DeGeneresről azt mondják, hiába tűnik barátságosnak, az egyik legundokabb tévés - Egykori testőre és egyik vendége is egyetért abban, hogy a humorista nem szeret köszönni, de néhány rajongója is nagyot csalódott benne az évek során 2-3 zile. Specialităţi. Boli infectioase. Detalii test. Detecția anticorpilor specifici anti SARS-CoV-2 de tip IgM permite evidențierea infecțiilor acute. Testele IgM pozitive ar trebui confirmate cu teste RT-PCR, deoarece un test IgM pozitiv poate apărea și la persoane vindecate, ceea ce limitează foarte mult utilitatea acestei metode. Paliloamele NU sunt alunițe. Papilomul pe pleoapa inferioară: cauze și metode de tratament Tipuri de papiloame Unele papiloame sunt date de infectia cu virusul papiloma uman — virusul HPV. Pot să apară la scurt timp de la infectare sau după mai mulți ani. Papiloamele cutanate pot să apară în orice zonă, de la nivelul gâtului, la. Seyfried TN, Huysentruyt LC. On the origin of cancer metastasis.Crit Rev Oncog. 2013;18(1-2):43-73.. Susan G. Komen. Lymph Node Status.Updated September 6, 2019. Kang YJ, Han W, Park S, et al. Outcome following sentinel lymph node biopsy-guided decisions in breast cancer patients with conversion from positive to negative axillary lymph nodes after neoadjuvant chemotherapy

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Ki67 is a special stain that gives a sense of how aggressive a tumor is. The pathologist takes the biopsy or surgical specimen, prepares it, puts it on to a glass slide, stains it for this protein, and look at it under the microscope. It's a protein in cells that is involved in cell replication, so if many cells are expressing it, the tumor is. Actualitatea Hîncești ⓜ mapamond domains | Actualitatea Moldovei | Новости | Moldova | Молдавия. De Actualitate. A first glimpse at Java 9: Early access release of JDK9 on OpenJDK 2. Focus on behavior and not the individual. Constructive feedback should be about what the individual did rather than who the individual is. 3. Focus on things that can be changed. Constructive feedback should be about things that a person can change and improve on rather than on something that is out of his/her control. 4

Un nou tratament eficient pentru cancerul de stomac

A Star Wars: Az utolsó Jedik vagy Star Wars VIII. rész - Az utolsó Jedik (eredeti cím: Star Wars: The Last Jedi) 2017 -ben bemutatott egész estés amerikai film, amely a Csillagok háborúja sorozat nyolcadik része, valamint a folytatástrilógia második filmje Az ébredő Erő után. A filmet Rian Johnson írta és rendezte Her-2/neu wird zusammen mit dem Hormon Rezeptor Status bestimmt. Bei Patientinnen mit ER- und/oder PR-positiven Tumoren kann bei Positivität von Her-2/neu das Ansprechen der endokrinen Therapie verringert sein. Der Hormon Rezeptor Status kann nicht in jedem Labor bestimmt werden DARQ tells the story of Lloyd, a boy who becomes aware of the fact that he is dreaming. To Lloyd's misfortune, the dream quickly turns into a nightmare and all attempts to wake up end in failure. While exploring the darkest corners of his subconscious, Lloyd learns how to survive the nightmare by bending the laws of physics and manipulating the.

Banca Naţională a României a raportat un profit de 2,03 miliarde de lei în 2020, în creştere cu 13% comparativ cu 2019, potrivit raportului anual dat publicităţii. În anul 2020, rezultatul operațional al Băncii (excluzând cheltuielile cu diferențele nefavorabile din reevaluarea activelor nete în valută) a fost pozitiv și a crescut semnificativ față de anul anterior, respectiv. synopsis. A frontal portrait of heroin addiction, Petit Samedi (Little Samedi) has all it takes to make very different types of audiences interested. It has a protagonist that one can easily grow fond of, Samedi, a man leading a quiet life somewhere in a Belgian village, far from the temptations of youth If the AMH is above 1.2, we feel relatively reassured. If the AMH level is less than 1.2, that is more concerning. Of course, this will also correlate with a woman's age, so a woman in her early 30s with a low AMH less than 1.2 is very worrisome, whereas it's more common for women in their early 40s to have a low AMH A virág, ha nem kap éltető vizet, elhervad, ha az emberi szív nem kap szeretetet, nem tud viszonozni, eluralkodik érzései felett a kétségbeesés, a közöny, végül teljesen kihűl. Syndie Maison. Szeretet. 29. Egy boldog pillanat nem más, csak színes vadvirág, Mi elhervad, míg haza sem érsz Millennium 2 is the second episode of Aldorlea's flagship series (the makers behind The Book of Legends, Moonchild, Dreamscape, 3 Stars of Destiny, Asguaard, Undefeated etc.). Featuring an immersive story, this game is a fantastic chapter to a series greenlighted by the Steam community that spans over 5 episodes and features more than 20.

Anne Mugo November 25, 2020 2. Listen!! No one but you can ever understand the magnitude of any form of violation, to your body or work. They can only imagine and. Continue Reading. Adolescent Girls and Young Women at the Center of the Response Căsătorie Uniune civilă Recunoaștere internă limitată (coabitare) Recunoaștere externă limitată (drepturi de rezidență) Nerecunoscute Constituția limitează căsătoria la cupluri formate din persoane de sex opus. ¹ Pot include legi recente sau hotărâri judecătorești care încă nu au intrat în vigoare. v • d • m România este una dintre țările europene care nu acordă. Million Reasons este un cântec al interpretei americane Lady Gaga pentru cel de-al cincilea ei album de studio, Joanne (2016). Lansat inițial drept un disc single promoțional, melodia a devenit cel de-al doilea disc single al albumului și a fost pentru prima dată difuzată de posturile de radio la 8 noiembrie 2016.Piesa a fost compusă de Gaga, Hillary Lindsey și Mark Ronson, iar. Mathematica 10 released on Raspberry Pi. admin - 19 mai 2020. Style Hunter

HER-2/neu:+++ (ponovo) / Rak dojke / Bolesti i stanja

A Wikimédia Commons tartalmaz Prijanka Csopra témájú médiaállományokat. Priyanka Chopra Jonas ( hindiül: प्रियंका चोपड़ा, nyugaton Priyanka Chopra; Dzsamsedpur, 1982. július 18. -) indiai színésznő, énekesnő, filmproducer és a Miss World 2000 szépségverseny nyertese Durata: 102 minute Categorie: Animatie Calitate film: BRRip Regizor: Chris Buck, Jennifer Lee Limba: English Descriere: Când o profeţie malefică face ca un întreg regat să se cufunde într-o iarnă veşnică, tânăra Anna va trebui să facă echipă cu Kristoff, un alpinist plin de întrăzneală, pentru a porni în căutarea Crăiesei Zăpezii, singura care ar putea pune capăt. Cancerul her2 pozitiv treatment for breast duct papilloma, multiple basal cell papillomas tratamentul viermilor la copii 1 5 papilloma virus or hpv. Viermii si parazitii intestinali. Hpv in laryngeal cancer paraziti goana dupa iluzi, metode rapide de detoxifiere sirop impotriva viermilor intestinali POZİTİF ( + ) KÖŞE ». POZİTİF HAYATA DAİR. Sayfa: [ 1] 2 3 12. Konu / Başlatan. Yanıt / Gösterim. Son İleti. 0 Üye ve 10 Ziyaretçi bölümü incelemekte. POZİTİF DOSTU DOKTOR, HASTANE VE KURUMLAR A '80-as évek végén, Oh Dae-soo-t, a teljesen átlagos családapát elrabolják saját háza elől és évekig fogva tartják egy privát cellában, ahol az egyetlen kapcsolatot a külvilággal egy televízió jelenti számára. Így szerez tudomást róla, hogy feleségét megölték és a rendőrség őt gyanúsítja. Értelmetlen és érthetetlen fogvatartása a kezdeti kétségbeesés.

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O sursă de informare corectă, nealimentată de panică poate ajuta populația României să fie vigilentă în felul în care accesează, asimilează și distribuie rafalele de știri prezentate în media. Informați-vă doar din canalele media oficiale și verificați informațiile de fiecare Whether you are a man or a woman, an abnormal BRCA1, BRCA2, or PALB2 genetic test result means there is a 50% chance you could have passed that specific mutation on to your children. While rare, it is possible for a person to have one BRCA1 and one BRCA2 mutation. Usually, this occurs in someone with Ashkenazi Jewish ancestry, due to the higher. Welcome back to the STD forum and thanks for your question. This sequence of events is the usual one for abnormal pap smears and cervical HPV infection. Most genital HPV infections are acquired before age 25, then disappear. Most infections don't reactivate, but a few do so. That's why having HPV, especially with a high risk type like HPV-16. Giftcreations123. Regular Member. Joined : May 2014. Posts : 129. Posted 7/4/2014 2:59 PM (GMT -6) My doctor recently discovered weak positive (30) elevated CCP antibodies but negstive RF. Went to rhuematologist who was obnoxious but anyway she felt my joints looked fine and must be false positive

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Metastatic Breast Cancer Forum 2018: HER2-positive Breast

Evaluări după categorie. 3,5 Echilibrul muncă/viață personală. 3,4 Salariu și beneficii. 3,2 Siguranța locului de muncă și promovare. 3,1 Conducere. 3,3 Cultura She has done her homework,hasn't she?(verbul to have e auxiliar.In prima parte e forma lui afirmativa,asadar,in a doua va fi negativa). Traducere:Si-a facut tema,nu-i asa? They made a mistake,didn't they?(verbul to make se deduce ca are auxiliarul do la trecut,adica did;se observa ca in prima e forma afirmativa,deci in a doua va fi negativa) 我的御2是01.00.0400固件版本 我购买了nld 给御 2降级 到15%的时候会停顿 总是失败 导致我一直无法破解nfz 所以希望nld尽快回复我具体原因 Thanks to this fantastic application, I was able to clean the NFZ database of my two Mavic Pro Platinum (Firmware .0300) After the purchase, i.. Děkuji všem, kteří se zapojili do konverzace a zase oživili naše fórum (i když negativním tématem). Československá komunita přece jenom dokáže držet při sobě a rozumně diskutovat. A ještě jednou - velké díky patří Vám všem. A doufám, že se tady bude řešit méně problémů a více pozitiv Pagina 2 din 30 - Nasterea acasa (in cada) - postat in Discutii generale: Dar ce relevanta are cine este si ce-a facut Ana Maita? este vorba strict despre o femeie careia nu i s-a dat voie sa alapteze. Ce importanta are unde a nascut, cat de asistata medical a fost la nastere, etc??? Putea sa fie in locul ei oricare alta femeie.... Ioana, [zana]Rebeca (16.05.2004), Sara (17.04.2009) si 24.

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Imunohistochimie - secțiunea

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Eladó: Avon Luck La Vie EDP

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